研究開発・学会発表
診療・治療
The Journal of Reproductive Medicine
- Effectiveness of 2-step (Consecutive) EmbryoTransfer Comparison with Cleavage-stage Transfer
- Vol.48 No.5, May 2003
- The Journal of Reproductive Medicine
- Sakae Goto, M.D., Ph.D., Koichi Takebayashi, M.D., Ph.D., Masahide Shiotani, M.D., Ph.D., Mutsuko Fujiwara, M.D., Masaya Hirose, M.D., Ph.D., and Yoichi Noda,M.D., Ph.D. From the Department of Obstetrics and Gynecology, Shiga University of Medical Science,Otsu, and Hanabusa Women's Clinic, kobe,Japan.
【発表の概要】
2-Step ET is an effective option.
OBJECTIVE: To evaluate the effectiveness of 2-step (consecutive) embryo transfer (ET),in which two cleaved embryos are transferred on day 2 (first step of ET) and a single blastocyst is transferred on day 5 (second step of ET) in comparison with conventional day 2 ET.
STUDY DESIGN: Observational comparative study at different time periods. Subjects were those who had ≧4 embryos On day 2 after oocyte retrieval. Those in the conventional group (n=60) received conventional day 2 ET,in which 3 cleaved embryos were transferred on day 2 between January 1999 and June 2000. Those in the 2-step group (n=124) received 2-step embryo transfer, in which 2 cleaved embryos were transferred on day 2 and a blastocyst was transferred on day 5 between September 2000 and February 2002. Patients who planned to receive 2-step ET but could not proceed to the second step of ET because of failure to produce blastocysts were included in the 2-step group.
RESULTS: The ongoing pregnancy rate with 2-step ET (51.6％) was significantly higher than with conventional ET (26.7％) (P <.01). The clinical pregnancy rate and implantation rate in conventional and 2-step ET were 30.0％ vs. 59.7％ and 11.1％ vs. 27.8％, respectively (P<.001).
CONCLUSION: Two-step ET may benefit patients who can obtain a sufficient number of embryos. (J Reprod Med 2003;48:370-374)
