研究開発・学会発表

Abstract
Purpose: The purpose of the study was to invent and evaluate the novel artificial intelligence
(AI) system named Fertility image Testing Through Embryo (FiTTE) for predicting
blastocyst viability and visualizing the explanations via gradient-based
localization.
Methods: The authors retrospectively analyzed 19 342 static blastocyst images with
related inspection histories from 9961 infertile patients who underwent in vitro fertilization.
Among these data, 17 984 cycles of single-blastocyst
transfer were used for
training, and data from 1358 cycles were used for testing purposes.
Results: The prediction accuracy for clinical pregnancy achieved by a control model
using conventional Gardner scoring system was 59.8%, and area under the curve
(AUC) was 0.62. FiTTE improved the prediction accuracy by using blastocyst images
to 62.7% and AUC of 0.68. Additionally, the accuracy achieved by an ensemble model
using image plus clinical data was 65.2% and AUC was 0.71, representing an improvement
in prediction accuracy. The visualization algorithm showed brighter colors with
blastocysts that resulted in clinical pregnancy.
Conclusions: The authors invented the novel AI system, FiTTE, which could provide
more precise prediction of the probability of clinical pregnancy using blastocyst images
secondary to single embryo transfer than the conventional Gardner scoring
assessments. FiTTE could also provide explanation of AI prediction using colored
blastocyst images.